This article is presented to you by the Immortality Foundation. Functional loss of stem cells plays a vital role in the aging process. Characterized by dysfunction of multiple tissues and organs, aging results from the reduced function of effective stem cell populations. Reversing age-related stem cell decline has long been a topic of considerable interest in longevity science. Recent advances in anti-aging research have uncovered the tremendous potential of stem cell therapy, as a way to achieve organismic rejuvenation . Stem cells are undifferentiated cells of a multicellular organism which are capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cell arise by differentiation.
Jump to navigation. An adult stem cell is thought to be an undifferentiated cell, found among differentiated cells in a tissue or organ. The adult stem cell can renew itself and can differentiate to yield some or all of the major specialized cell types of the tissue or organ. The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found.
Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow BM transplantation or peripheral blood stem cells PBSC transplantation is the pioneer of cellular therapy and translational research. However, stem cell research field is developing so fast that, innovative approaches using HSCs for treatment of refractory diseases are growing rapidly. Hematopoietic stem cell transplantation HSCT has been widely used to achieve cure in different hematological diseases.